Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796131 | 0.86 | NPC1 (0.47) | RAD52UHRF1KDM4ERAB9ANPC1 | |
| SCHEMBL5799064 | 0.86 | RAD52 (0.56) | RAD52UHRF1KDM4ERAB9ANPC1 | |
| SCHEMBL5795249 | 0.80 | KDM4E (0.55) | RAD52UHRF1KDM4EDHODHPOLB | |
| SCHEMBL5798941 | 0.79 | MAPT (0.51) | KDM4ERAB9ANPC1KMT2AGAA | |
| SCHEMBL8270336 | 0.78 | PDE4D (0.51) | — | |
| SCHEMBL6068261 | 0.75 | KDM4E (0.68) | KDM4ETDP1GAAALDH1A1 | |
| SCHEMBL13425642 | 0.75 | RAD52 (0.48) | RAD52UHRF1KDM4ERAB9ADHODH | |
| SCHEMBL5796954 | 0.75 | RAD52 (0.54) | RAD52UHRF1KDM4ERAB9ANPC1 | |
| SCHEMBL27546693 | 0.74 | KDM4E (0.56) | KDM4ERAB9ANPC1DHODHPOLB | |
| SCHEMBL2445471 | 0.74 | RAD52 (0.47) | RAD52UHRF1KDM4ERAB9ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006040650-A1 | 4-METHOXYACRIDINE-1-CARBOXAMIDE DERIVATIVES AND THE PHENAZINE AND OXANTHRENE ANALOGS AS PDE4-INHIBITORS FOR THE TREATMENT OF ASTHMA AND CHRONIC PULMONARY DISEASE (COPD) | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-04-20 | — | — | WO | disclosed |