Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | TPH1 | P17752 | 1/20 | 0.43 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9063730 | 0.88 | GRIN1 (0.51) | GRIN1GRIN2BGAAPKMEGFR | |
| SCHEMBL23280122 | 0.83 | GRIN1 (0.52) | GRIN1GRIN2BGAAPKMTSHR | |
| SCHEMBL23280180 | 0.83 | GRIN1 (0.52) | GRIN1GRIN2BGAAMAPTNPC1 | |
| SCHEMBL7265526 | 0.82 | GAA (0.69) | GRIN1GRIN2BGAAPKMTSHR | |
| SCHEMBL23280058 | 0.81 | GRIN1 (0.58) | GRIN1GRIN2BGAAMAPTNPC1 | |
| SCHEMBL7019918 | 0.80 | GAA (0.54) | GRIN1GRIN2BGAAPKMTSHR | |
| SCHEMBL8324999 | 0.80 | HDAC1 (0.53) | GRIN1GRIN2BMAPK10 | |
| SCHEMBL7653718 | 0.79 | TDP1 (0.47) | GRIN1GRIN2BTDP1KMT2ACYP19A1 | |
| SCHEMBL485969 | 0.79 | GRIN1 (0.43) | GRIN1GRIN2BKDM4EKMT2ACYP19A1 | |
| SCHEMBL7765425 | 0.79 | DDAH1 (0.53) | GRIN1GRIN2BGAAKMT2ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615636-A1 | BICYCLIC COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089366-A1 | BICYCLIC COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS | PFIZER JAPAN, INC. (JP) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204409-A1 | Bicyclic compounds as NR2B receptor antagonists | ANDO KAZUO (JP) | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204409-A1 | Bicyclic compounds as NR2B receptor antagonists | GRIN1, GRIN2B, GRIN2A | GRIN1 1/4885GRIN2B 2/4885GAA 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.