Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797263 | 0.90 | TP53 (0.39) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5794582 | 0.88 | TP53 (0.39) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5795308 | 0.88 | TP53 (0.39) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5794793 | 0.88 | TP53 (0.39) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5795812 | 0.88 | TP53 (0.39) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5793330 | 0.87 | TP53 (0.43) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5795269 | 0.87 | MEN1 (0.40) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5795248 | 0.83 | SRD5A1 (0.41) | TP53IGF1RTRIM24TRIM33RAPGEF4 | |
| SCHEMBL5794232 | 0.83 | BRD4 (0.42) | HTR6KMT2AGAAHPGDALDH1A1 | |
| SCHEMBL5797613 | 0.82 | RAPGEF4 (0.39) | TP53IGF1RTRIM24TRIM33RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732546-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |