Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29677764 | 0.71 | CYP1A2 (0.77) | MAPTKDM4ECYP1A2ALDH1A1RAB9A | |
| SCHEMBL465841 | 0.71 | CYP1A2 (0.77) | MAPTKDM4ECYP1A2ALDH1A1RAB9A | |
| SCHEMBL5967143 | 0.70 | XIAP (0.46) | MAPTKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL30753583 | 0.70 | XIAP (0.46) | MAPTKDM4EALDH1A1RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL6741600 | 0.70 | CYP1A2 (0.74) | MAPTKDM4ECYP1A2ALDH1A1RAB9A | |
| SCHEMBL7230001 | 0.70 | CPB2 (0.44) | MAPTKDM4ENOS3NOS2XIAP | |
| SCHEMBL23582234 | 0.70 | MAPT (0.46) | MAPTKDM4ECYP1A2ALDH1A1RAB9A | |
| SCHEMBL31357620 | 0.70 | MAPT (0.46) | MAPTKDM4ECYP1A2ALDH1A1RAB9A | |
| SCHEMBL14733028 | 0.69 | KDM4E (0.38) | MAPTKDM4ECYP1A2ALDH1A1RAB9A | |
| SCHEMBL5693092 | 0.69 | CHEK1 (0.50) | MAPTKDM4ECYP1A2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |