SCHEMBL5796107

SCHEMBL5796107

Cn1ccc2c3c(N)nc(N)nc3c(I)c(-c3ccccc3CCC(=O)O)c21

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DHFR P00374 6/20 0.36
PTGER1 P34995 2/20 0.33
PTGER4 P35408 2/20 0.33
PTGER3 P43115 2/20 0.33
PTGER2 P43116 2/20 0.33
CMA1 P23946 1/20 0.33
ADORA2A P29274 2/20 0.33
HDAC6 Q9UBN7 2/20 0.31
GSK3B P49841 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP3A4 P08684 1/20 0.31
HPGD P15428 1/20 0.31
PIK3CD O00329 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
HTR2B P41595 1/20 0.30
GPR68 Q15743 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5799326 0.82 FFAR1 (0.43) DHFR
SCHEMBL5773193 0.81 DHFR (0.34) DHFR
SCHEMBL4691092 0.80 DHFR (0.42) DHFRPTGER1PTGER4PTGER3PTGER2
SCHEMBL5795879 0.79 PARP1 (0.38) DHFRPTGER1PTGER4PTGER3PTGER2
SCHEMBL5798079 0.76 CDK2 (0.39) DHFRALDH1A1HPGD
SCHEMBL5797300 0.73 POLB (0.43) DHFRALDH1A1HPGDMEN1KMT2A
SCHEMBL5798083 0.72 DHFR (0.36) DHFRADORA2AHDAC6
SCHEMBL5798735 0.72 DHFR (0.36) DHFR
SCHEMBL5795813 0.72 PTPN1 (0.34) ADORA2ACYP3A4KMT2A
SCHEMBL5798382 0.71 PIK3CG (0.41) DHFRADORA2AHDAC6CYP3A4PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1628979-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-01 EP claimed
WO-2004101568-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-11-25 WO claimed
EP-1628979-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-01 EP disclosed
WO-2004101568-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-11-25 WO disclosed