Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 12/20 | 0.49 |
| ▸ | EGFR | P00533 | 8/20 | 0.43 |
| ▸ | CSF1R | P07333 | 6/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398349 | 1.00 | FGFR4 (0.49) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL4398347 | 1.00 | FGFR4 (0.49) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL4404620 | 0.93 | FGFR4 (0.48) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL4403173 | 0.93 | FGFR4 (0.48) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL4403892 | 0.93 | FGFR4 (0.48) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL4403935 | 0.89 | FGFR4 (0.55) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4403932 | 0.89 | FGFR4 (0.55) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4408936 | 0.88 | FGFR4 (0.49) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL6227767 | 0.88 | FGFR4 (0.49) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL5798952 | 0.83 | FGFR4 (0.52) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038112-A1 | USE OF KINASE INHIBITORS TO PROMOTE NEOCHONDROGENESIS | WARNER-LAMBERT COMPANY LLC (US) | 2006-04-13 | — | — | WO | disclosed |
| EP-1549651-A1 | KINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011465-A1 | KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-05 | — | — | WO | disclosed |