Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.41 |
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794491 | 0.91 | GSK3B (0.39) | KDRGSK3BKDM4ERCE1DRD2 | |
| SCHEMBL5797776 | 0.84 | KDM4E (0.44) | KDRGSK3BKDM4ERCE1MAPK1 | |
| SCHEMBL5793991 | 0.79 | KDR (0.43) | KDRGSK3BKDM4ERCE1MAPK1 | |
| SCHEMBL1748831 | 0.79 | IGF1R (0.46) | KDRGSK3BKDM4ERCE1MAPK1 | |
| SCHEMBL1779928 | 0.78 | IGF1R (0.66) | KDRGSK3BKDM4ERCE1CNR1 | |
| SCHEMBL1749184 | 0.78 | CDK9 (0.43) | KDRKDM4ERCE1CCNT1CDK9 | |
| SCHEMBL1748609 | 0.77 | CDK9 (0.47) | KDRGSK3BKDM4ERCE1CCNT1 | |
| SCHEMBL5797872 | 0.77 | IGF1R (0.55) | KDRGSK3BKDM4ECDK9 | |
| SCHEMBL5795129 | 0.72 | GSK3B (0.42) | KDRGSK3BCNR1DRD2DRD3 | |
| SCHEMBL5822423 | 0.72 | TP53 (0.43) | KDRGSK3BKDM4ERCE1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732546-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |