Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27791569 | 0.79 | KDM4E (0.55) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL5796700 | 0.79 | KDM4E (0.50) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL7618500 | 0.78 | KDM4E (0.70) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL2011634 | 0.77 | KDM4E (0.57) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL31086815 | 0.77 | KDM4E (0.57) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL27497486 | 0.72 | KDM4E (0.68) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL2311114 | 0.71 | KDM4E (0.50) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL11779790 | 0.71 | KDM4E (0.59) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL3461908 | 0.70 | TSHR (0.57) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL1642463 | 0.70 | ALDH1A1 (0.52) | KDM4EHCAR2TSHRTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111039932-A | High-yield synthesis method of ladostinib | 安徽峆一药业股份有限公司 | 2020-04-21 | — | — | CN | claimed |
| CN-111039932-A | High-yield synthesis method of ladostinib | 安徽峆一药业股份有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-111039932-A | High-yield synthesis method of ladostinib | 安徽峆一药业股份有限公司 | 2020-04-21 | — | — | CN | disclosed |
| EP-1735319-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005092899-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2005-10-06 | — | — | WO | disclosed |