Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995781 | 0.78 | IDO1 (0.52) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL803464 | 0.76 | IDO1 (0.50) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL10665108 | 0.76 | IDO1 (0.56) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL15746545 | 0.76 | IDO1 (0.50) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL11588057 | 0.73 | TAAR1 (0.59) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL4957510 | 0.73 | IDO1 (0.46) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL1457250 | 0.71 | MIF (0.52) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL14911695 | 0.71 | IDO1 (0.45) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL325486 | 0.71 | IDO1 (0.45) | IDO1PNMTTAAR1HTR3EHTR3B | |
| SCHEMBL4023670 | 0.71 | TAAR1 (0.73) | IDO1PNMTTAAR1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638944-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000821-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |