Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.44 |
| ▸ | PDE4A | P27815 | 6/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797239 | 0.79 | PDE4D (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL30735868 | 0.76 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7421344 | 0.76 | CA1 (0.36) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5793632 | 0.76 | KDM4E (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL20455985 | 0.75 | PDE4D (0.40) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL28167810 | 0.74 | CA1 (0.40) | PDE4B | |
| SCHEMBL20456502 | 0.74 | ERN1 (0.42) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4402862 | 0.73 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL636252 | 0.73 | SRC (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5796942 | 0.73 | CA1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006040645-A1 | N-(3,5-DICHLOROPYRIDIN-4-YL)-2,4,5-ALKOXY AND 2,3,4-ALKOXY BENZAMIDE DERIVATIVES AS PDE-IV (PHOPHODIESTERASE TYPE-IV) INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES SUCH AS ASTHMA | RANBAXY LABORATORIES LIMITED (IN) | 2006-04-20 | — | — | WO | disclosed |