Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.88 |
| ▸ | SLC6A4 | P31645 | 16/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884392 | 0.91 | TACR1 (0.75) | TACR1SLC6A4KCNH2 | |
| SCHEMBL3888046 | 0.87 | TACR1 (0.79) | TACR1SLC6A4KCNH2 | |
| SCHEMBL3896842 | 0.85 | TACR1 (1.00) | TACR1SLC6A4KCNH2 | |
| SCHEMBL5388727 | 0.84 | TACR1 (0.73) | TACR1SLC6A4 | |
| SCHEMBL5796868 | 0.83 | TACR1 (0.70) | TACR1SLC6A4 | |
| SCHEMBL5794588 | 0.83 | TACR1 (1.00) | TACR1SLC6A4KCNH2 | |
| SCHEMBL1388258 | 0.83 | TACR1 (1.00) | TACR1SLC6A4KCNH2 | |
| SCHEMBL5374540 | 0.81 | TACR1 (0.71) | TACR1SLC6A4 | |
| SCHEMBL1388428 | 0.80 | TACR1 (1.00) | TACR1SLC6A4KCNH2 | |
| SCHEMBL3886400 | 0.80 | TACR1 (1.00) | TACR1SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098203-B2 | Homopiperidine derivatives as NK-1 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-29 | — | — | US | disclosed |
| WO-2006014703-A2 | HOMOPIPERDININE DERIVATIVES AS NK-1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060019943-A1 | Homopiperidine derivatives as NK-1 antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019943-A1 | Homopiperidine derivatives as NK-1 antagonists | HTR1D, HTR5A, SLC6A4 | TACR1 9/4885SLC6A4 3/4885KCNH2 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.