Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4141303 | 0.87 | PIK3CD (0.48) | PIK3CDKDM4EALDH1A1PTPN11HSD11B1 | |
| SCHEMBL5801307 | 0.85 | PIK3CD (0.49) | PIK3CDKDM4EALDH1A1PTPN11HTT | |
| SCHEMBL5799288 | 0.84 | PIK3CD (0.54) | PIK3CDKDM4EALDH1A1PTPN11HTT | |
| SCHEMBL5201356 | 0.75 | PIK3CD (0.59) | PIK3CDALDH1A1PTPN11HSD11B1POLB | |
| SCHEMBL4148915 | 0.75 | KDM4E (0.52) | PIK3CDKDM4EALDH1A1HTTHSD11B1 | |
| SCHEMBL4132317 | 0.75 | PIK3CD (0.56) | PIK3CDKDM4EALDH1A1PTPN11HSD11B1 | |
| SCHEMBL4131816 | 0.74 | PIK3CD (0.63) | PIK3CDKDM4EALDH1A1PTPN11HSD11B1 | |
| SCHEMBL4134742 | 0.73 | PIK3CD (0.65) | PIK3CDKDM4EALDH1A1PTPN11HSD11B1 | |
| SCHEMBL4141107 | 0.73 | PIK3CD (0.65) | PIK3CDKDM4EALDH1A1PTPN11HSD11B1 | |
| SCHEMBL4141427 | 0.73 | PIK3CD (0.65) | PIK3CDKDM4EALDH1A1PTPN11HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682532-A1 | PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE-3-KINASES (PI3K) | Warner-Lambert Company LLC (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005042519-A1 | PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE -3-KINASES (PI3K) | WARNER-LAMBERT COMPANY LLC (US) | 2005-05-12 | — | — | WO | claimed |