Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4149893 | 0.88 | PIK3CD (0.51) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL5797335 | 0.84 | PIK3CD (0.53) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL5801307 | 0.80 | PIK3CD (0.49) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL5203254 | 0.77 | PIK3CD (0.60) | PIK3CDHSD11B1PTPN11SCN9A | |
| SCHEMBL4131816 | 0.76 | PIK3CD (0.63) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL4141427 | 0.75 | PIK3CD (0.65) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL4141107 | 0.75 | PIK3CD (0.65) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL4134742 | 0.75 | PIK3CD (0.65) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL4132317 | 0.73 | PIK3CD (0.56) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 | |
| SCHEMBL4141303 | 0.70 | PIK3CD (0.48) | PIK3CDHSD11B1KDM4EALDH1A1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682532-A1 | PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE-3-KINASES (PI3K) | Warner-Lambert Company LLC (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005042519-A1 | PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE -3-KINASES (PI3K) | WARNER-LAMBERT COMPANY LLC (US) | 2005-05-12 | — | — | WO | claimed |