Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799224 | 0.83 | MAPK13 (0.37) | NTSR1MAP4K1KMT2AMEN1MAPT | |
| SCHEMBL5797441 | 0.78 | MAPK8 (0.42) | MAPK8BTKMRGPRX2MAPK10ADRA1B | |
| SCHEMBL5795722 | 0.77 | MCHR1 (0.36) | MAPK8BTKMRGPRX2MAPK10ADRA1B | |
| SCHEMBL5795738 | 0.77 | MAPK13 (0.46) | MAPK8BTKMRGPRX2MAPK10HTR1D | |
| SCHEMBL5797429 | 0.76 | MAPK8 (0.38) | MAPK8BTKMRGPRX2MAPK10ADRA1B | |
| SCHEMBL5798480 | 0.74 | MAPK13 (0.40) | MAPK8BTKMRGPRX2MAPK10MAPT | |
| SCHEMBL5796363 | 0.74 | SLC5A1 (0.37) | MAPK8BTKMRGPRX2MAPK10ADRA1B | |
| SCHEMBL5796380 | 0.73 | MAPK11 (0.39) | MAPK8BTKMRGPRX2MAPK10SMN1; SMN2 | |
| SCHEMBL5795724 | 0.72 | MAPK13 (0.37) | MAPK8BTKMRGPRX2MAPK10MAPT | |
| SCHEMBL5813023 | 0.72 | CYP2C9 (0.37) | MAPK8BTKMRGPRX2MAPK10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |