Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.33 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795722 | 0.92 | MCHR1 (0.36) | MAPK13CYP2C9MAPK11SMN1; SMN2KMT2A | |
| SCHEMBL5795738 | 0.91 | MAPK13 (0.46) | MAPK13CYP2C9MAPK11SMN1; SMN2NPSR1 | |
| SCHEMBL5796380 | 0.90 | MAPK11 (0.39) | MAPK13CYP2C9MAPK11SMN1; SMN2TSHR | |
| SCHEMBL5813023 | 0.89 | CYP2C9 (0.37) | MAPK13CYP2C9MAPK11SMN1; SMN2TSHR | |
| SCHEMBL5817772 | 0.88 | MAPK13 (0.40) | MAPK13CYP2C9MAPK11SMN1; SMN2MAPT | |
| SCHEMBL5798480 | 0.88 | MAPK13 (0.40) | MAPK13CYP2C9MAPK11SMN1; SMN2NPSR1 | |
| SCHEMBL5795724 | 0.84 | MAPK13 (0.37) | MAPK13CYP2C9MAPK11NPSR1MAPT | |
| SCHEMBL5797394 | 0.83 | MAPK8 (0.40) | CYP2C9SMN1; SMN2KMT2AMEN1NPSR1 | |
| SCHEMBL5796356 | 0.79 | MAPK13 (0.40) | MAPK13CYP2C9MAPK11SMN1; SMN2MAP4K1 | |
| SCHEMBL5797429 | 0.79 | MAPK8 (0.38) | MAPK13CYP2C9MAPK11FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |