Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454254 | 0.77 | MTNR1A (0.53) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL2878241 | 0.74 | OPRL1 (0.40) | OPRL1P2RX7KCNH2 | |
| SCHEMBL5053493 | 0.73 | MTNR1A (0.64) | MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL5053490 | 0.73 | MTNR1A (0.64) | MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL1029693 | 0.71 | MTNR1A (0.77) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL30595323 | 0.71 | MTNR1A (0.77) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL3311831 | 0.70 | MTNR1A (0.64) | MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL14012294 | 0.70 | TRPV1 (0.52) | MTNR1AMTNR1BP2RX7CA1CA2 | |
| SCHEMBL5053483 | 0.70 | TRPV1 (0.52) | MTNR1AMTNR1BP2RX7CA1CA2 | |
| SCHEMBL31678106 | 0.70 | TRPV1 (0.52) | MTNR1AMTNR1BP2RX7CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006055462-A1 | 2-AMINO-4-FUNCTIONALIZED TETRALIN DERIVATIVES AND RELATED GLYCOGEN PHOSPHORYLASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-26 | — | — | WO | disclosed |