Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372302 | 0.85 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL13055383 | 0.85 | LMNA (0.80) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL21987005 | 0.84 | LMNA (0.74) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL11085496 | 0.84 | LMNA (0.74) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL35211277 | 0.84 | LMNA (0.74) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL30823376 | 0.84 | SMN1; SMN2 (0.97) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL25538805 | 0.84 | LMNA (0.79) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL5019074 | 0.83 | LMNA (0.73) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL23710739 | 0.83 | LMNA (0.72) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL21597890 | 0.83 | LMNA (0.72) | LMNASMN1; SMN2HTTL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006055462-A1 | 2-AMINO-4-FUNCTIONALIZED TETRALIN DERIVATIVES AND RELATED GLYCOGEN PHOSPHORYLASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-26 | — | — | WO | disclosed |