Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 18/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.45 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382473 | 0.88 | CASR (0.76) | CASRNR1I2 | |
| SCHEMBL3382240 | 0.83 | CASR (1.00) | CASR | |
| SCHEMBL4439206 | 0.83 | CASR (0.52) | CASRNR1I2 | |
| SCHEMBL5822471 | 0.80 | CASR (0.73) | CASRNR1I2 | |
| SCHEMBL5796090 | 0.80 | CASR (0.73) | CASRNR1I2 | |
| SCHEMBL5798839 | 0.79 | CASR (0.71) | CASRNR1I2 | |
| SCHEMBL5798841 | 0.79 | CASR (0.71) | CASRNR1I2 | |
| SCHEMBL5823507 | 0.79 | CASR (0.71) | CASRNR1I2 | |
| SCHEMBL5823509 | 0.79 | CASR (0.71) | CASRNR1I2 | |
| SCHEMBL5796763 | 0.79 | CASR (0.70) | CASRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066070-A2 | PRODRUG CONSTRUCTS OF PYRIMIDINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| WO-2006066070-A2 | PRODRUG CONSTRUCTS OF PYRIMIDINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |