Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797338 | 0.85 | MAPK14 (0.49) | MAPK13MAPK12MAPK11MAPK14TP53 | |
| SCHEMBL2080030 | 0.68 | SYK (0.46) | TP53LMNAGPR119CCNT1SMN1; SMN2 | |
| SCHEMBL15565385 | 0.66 | ALDH1A1 (0.56) | TP53LMNAGPR119MAPTSMN1; SMN2 | |
| SCHEMBL20817809 | 0.66 | ALDH1A1 (0.58) | TP53LMNAGPR119MAPTSMN1; SMN2 | |
| SCHEMBL13060185 | 0.66 | ALDH1A1 (0.55) | GPR119MAPTSMN1; SMN2 | |
| SCHEMBL4240260 | 0.65 | MAPK11 (0.53) | MAPK13MAPK12MAPK11MAPK14LMNA | |
| SCHEMBL2079602 | 0.64 | CCNT1 (0.49) | MAPK14TP53LMNAGPR119CCNT1 | |
| SCHEMBL2745591 | 0.64 | MAP4K4 (0.64) | MAPK13MAPK14CCNT1 | |
| SCHEMBL4244097 | 0.64 | MAPK11 (0.64) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10040508 | 0.64 | SMN1; SMN2 (0.53) | TP53LMNAGPR119MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |