Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653399 | 0.72 | HTR7 (0.44) | HTR7HRH4HTR1APLD1HTR2C | |
| SCHEMBL5317683 | 0.70 | SCN9A (0.52) | EPHX2HTR7HTR1APLD1HTR2C | |
| SCHEMBL2754180 | 0.69 | HRH4 (0.59) | HRH4 | |
| SCHEMBL10095065 | 0.68 | HTR7 (0.39) | EPHX2HTR7HTR1APLD1HTR2C | |
| SCHEMBL5799183 | 0.68 | EPHX2 (0.61) | EPHX2HRH4FLT3 | |
| SCHEMBL14060585 | 0.68 | HTR7 (0.70) | EPHX2HTR7HTR1APLD1HTR2C | |
| SCHEMBL31106280 | 0.68 | HTR7 (0.57) | HTR7HRH4HTR1APLD1HTR2C | |
| SCHEMBL20723340 | 0.68 | HRH4 (0.52) | HTR7HRH4HTR1A | |
| SCHEMBL5317680 | 0.68 | HTR7 (0.53) | EPHX2HTR7HTR1APLD1HTR2C | |
| SCHEMBL5800530 | 0.68 | EPHX2 (0.50) | EPHX2HTR7HTR1APLD1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644358-A2 | BIARYL PIPERAZINYL-PYRIDINE ANALOGUES | NEUROGEN CORPORATION (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005007648-A2 | BIARYL PIPERAZINYL-PYRIDINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |