Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798532 | 0.90 | MAPK13 (0.46) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5798634 | 0.89 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5797338 | 0.88 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5796466 | 0.88 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5796468 | 0.80 | MAPK11 (0.52) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5797305 | 0.80 | MAPK11 (0.55) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5795927 | 0.79 | MAPK11 (0.53) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5795633 | 0.78 | MAPK11 (0.49) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5795836 | 0.78 | MAPK13 (0.48) | MAPK14MAPK11MAPK13MAPK12CYP2C9 | |
| SCHEMBL5799438 | 0.77 | MAPK11 (0.61) | MAPK14MAPK11MAPK13MAPK12CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |