Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.74 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.74 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.74 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.74 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13983406 | 0.86 | PIK3CD (0.72) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL3761617 | 0.85 | PIK3CD (1.00) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL13654285 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL12765132 | 0.85 | PIK3CG (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL731743 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL13983063 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL15651392 | 0.82 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL8122267 | 0.82 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL3404369 | 0.82 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL15211940 | 0.81 | PIK3CG (0.63) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651595-A2 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005007621-A2 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |