Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1796669 | 1.00 | LSS (0.49) | LSSCHRNA7BCHEACHEGLA | |
| Fumaric Acid SCHEMBL1796664 | 1.00 | LSS (0.49) | LSSCHRNA7BCHEACHEGLA | |
| Fumaric Acid SCHEMBL1798513 | 0.96 | LSS (0.46) | LSSCHRNA7BCHEACHE | |
| Fumaric Acid SCHEMBL1798517 | 0.96 | LSS (0.46) | LSSCHRNA7BCHEACHE | |
| SCHEMBL1794584 | 0.90 | LSS (0.51) | LSSCHRNA7 | |
| SCHEMBL1795878 | 0.90 | LSS (0.51) | LSSCHRNA7 | |
| SCHEMBL2850377 | 0.90 | LSS (0.51) | LSSCHRNA7 | |
| SCHEMBL1795607 | 0.85 | LSS (0.47) | LSS | |
| SCHEMBL1799249 | 0.85 | LSS (0.47) | LSS | |
| SCHEMBL1793463 | 0.83 | LSS (0.45) | LSSCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |