Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800109 | 1.00 | NR1H4 (0.42) | NR1H4AGTR1ESRRGALDH1A1PPARG | |
| SCHEMBL1484330 | 0.91 | AGTR1 (0.46) | NR1H4AGTR1ESRRGALDH1A1KDM4E | |
| SCHEMBL12829728 | 0.91 | AGTR1 (0.46) | NR1H4AGTR1ESRRGALDH1A1KDM4E | |
| SCHEMBL1484332 | 0.91 | AGTR1 (0.46) | NR1H4AGTR1ESRRGALDH1A1KDM4E | |
| SCHEMBL12755620 | 0.90 | AGTR1 (0.46) | AGTR1ESRRGALDH1A1KDM4EMEN1 | |
| SCHEMBL1483392 | 0.86 | AGTR1 (0.44) | AGTR1ESRRGALDH1A1KDM4EMEN1 | |
| SCHEMBL1483390 | 0.86 | AGTR1 (0.44) | AGTR1ESRRGALDH1A1KDM4EMEN1 | |
| SCHEMBL12755594 | 0.80 | TDP1 (0.45) | NR1H4ALDH1A1KMT2AMAPTLMNA | |
| SCHEMBL1483465 | 0.80 | TDP1 (0.45) | NR1H4ALDH1A1KMT2AMAPTLMNA | |
| SCHEMBL1483466 | 0.80 | TDP1 (0.45) | NR1H4ALDH1A1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636192-A1 | 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108683-A1 | 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2004-12-16 | — | — | WO | disclosed |