Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734044 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL734045 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL23962341 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL967471 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL968486 | 0.77 | HTT (0.50) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL8392707 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL24059132 | 0.77 | MMP1 (0.45) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL8391822 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL5824896 | 0.77 | CA12 (0.43) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL786679 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2CA12CA1CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006044133-A1 | ACTIVE KETONE INHIBITORS OF TRYPTASE | AXYS PHARMACEUTICALS, INC. (US) | 2006-04-27 | — | — | WO | disclosed |