SCHEMBL580084

SCHEMBL580084

C=CCOc1ccccc1[SiH3]

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.53
TSHR P16473 1/20 0.53
MAPK1 P28482 1/20 0.53
HSD17B10 Q99714 1/20 0.53
LIG1 P18858 1/20 0.50
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 2/20 0.45
SLC22A1 O15245 1/20 0.44
LMNA P02545 1/20 0.44
CYP1A2 P05177 1/20 0.44
ADRB2 P07550 1/20 0.44
ADRB1 P08588 1/20 0.44
HTR1A P08908 1/20 0.44
CYP2D6 P10635 1/20 0.44
HTR2A P28223 1/20 0.44
SLC6A4 P31645 1/20 0.44
ADRA1A P35348 1/20 0.44
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA9 Q16790 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1,2-Diallyloxybenzene SCHEMBL29768784 0.86 HPGD (0.60) HPGDTSHRMAPK1HSD17B10LIG1
1,2-Diallyloxybenzene SCHEMBL366516 0.86 HPGD (0.60) HPGDTSHRMAPK1HSD17B10LIG1
SCHEMBL7764770 0.80 HPGD (0.55) HPGDTSHRMAPK1HSD17B10LIG1
SCHEMBL3800333 0.80 HPGD (0.55) HPGDTSHRMAPK1HSD17B10LIG1
SCHEMBL28427811 0.78 HPGD (0.53) HPGDTSHRMAPK1HSD17B10LIG1
SCHEMBL910763 0.78 HPGD (0.53) HPGDTSHRMAPK1HSD17B10LIG1
1-Hydroxy-2-Allyloxybenzene SCHEMBL1562951 0.78 GAA (0.59) HPGDTSHRMAPK1HSD17B10LIG1
SCHEMBL10056648 0.77 HPGD (0.56) HPGDTSHRMAPK1HSD17B10LIG1
1-Allyloxy-2-Ethoxybenzene SCHEMBL11755537 0.77 HPGD (0.51) HPGDTSHRMAPK1HSD17B10LIG1
SCHEMBL995137 0.77 ALDH1A1 (0.59) HPGDTSHRMAPK1HSD17B10LIG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9192551-B2 Sun protection kit L'OREAL (FR) 2015-11-24 US disclosed
WO-2012131070-A2 USE OF A DEVICE FOR TRANSFERRING AN ANTIPERSPIRANT COSMETIC FILM APPLIED ONTO THE SKIN L'OREAL (FR) 2012-10-04 WO disclosed
WO-2012131068-A2 PROCESS COMPRISING THE APPLICATION OF AN ANTIPERSPIRANT MATERIAL CONTAINING AT LEAST TWO ZONES OF DIFFERENT POLYMERS L'OREAL (FR) 2012-10-04 WO disclosed
US-20120085364-A1 METHOD FOR MAKING UP EYELASHES L'OREAL (FR) 2012-04-12 US disclosed
EP-2416753-A2 EYELASH MAKE-UP PROCESS L'Oréal (FR) 2012-02-15 EP disclosed
WO-2010116079-A2 METHOD FOR MAKING UP EYELASHES L'OREAL (FR) 2010-10-14 WO disclosed
US-7780742-B2 Composition comprising a compound X and A compound Y, at least one of which is a silicone, and a hydrophobic direct dye L'OREAL S.A. (FR) 2010-08-24 US disclosed
US-20100179105-A1 KERATIN MATERIALS MAKE-UP KIT COMPRISING REACTIVE SILICONE COMPOUNDS AND A COMPATIBLE OIL L'OREAL S.A. (FR) 2010-07-15 US disclosed
US-7740664-B2 Composition comprising at least one silicone compound and at least one organosilane L'OREAL S.A. (FR) 2010-06-22 US disclosed
US-20100152135-A1 COSMETIC KIT COMPRISING REACTIVE SILICONE COMPOUNDS AND A GLOSSY OIL L'OREAL S.A. (FR) 2010-06-17 US disclosed
WO-2008075300-A1 METHOF FOR MAKING UP KERATINOUS SUBSTANCES AND KIT FOR THE IMPLEMENTATION OF SUCH A METHOD L'OREAL (FR) 2008-06-26 WO disclosed
WO-2008074870-A2 LASH COATING KIT COMPRISING SILICONE COMPOUNDS X AND Y AND FIBRES L'OREAL (FR) 2008-06-26 WO disclosed
WO-2008075301-A2 COSMETIC PRODUCT COMPRISING SILICONE COMPOUNDS AND REFLECTIVE PARTICLES WITH METALLIC REFLECTION L'OREAL (FR) 2008-06-26 WO disclosed
WO-2008075281-A2 CLEANSING COMPOSITION BASED ON ABSORBENT FILLERS AND SILICONE COMPOUNDS L'OREAL (FR) 2008-06-26 WO disclosed
EP-1935403-A2 Composition containing a compound x and a compound y, at least one of which is silicone, and a hydrophobic direct dye L'Oréal (FR) 2008-06-25 EP disclosed
EP-1935401-A2 Method for treating capillary fibres with compositions containing reactive silicones L'OREAL (FR) 2008-06-25 EP disclosed
WO-2007071885-A2 KIT COMPRISING A SILICONE OIL AND SILICONE COMPOUNDS X OR Y CAPABLE OF REACTING TOGETHER ON THE EYELASHES L'ORÉAL (FR) 2007-06-28 WO disclosed
WO-2007071886-A2 COMPOSITION COMPRISING A COMPOUND X AND A COMPOUND Y WHICH REACT TOGETHER, AT LEAST ONE OF WHICH IS A SILICONE COMPOUND, AND A CATIONIC SURFACTANT L'ORÉAL (FR) 2007-06-28 WO disclosed
US-4924021-A Cyclic phenol organosilanes and method for their preparation HUELS AKTIENGESELLSCHAFT (DE) 1990-05-08 US disclosed
US-4924021-A Cyclic phenol organosilanes and method for their preparation HUELS AKTIENGESELLSCHAFT (DE) 1990-05-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100179105-A1 KERATIN MATERIALS MAKE-UP KIT COMPRISING REACTIVE SILICONE COMPOUNDS AND A COMPATIBLE OIL KRT18, VIM, F12 HPGD 443/4885TSHR 4720/4885MAPK1 1550/4885
US-20100152135-A1 COSMETIC KIT COMPRISING REACTIVE SILICONE COMPOUNDS AND A GLOSSY OIL GK, KRT18, KIT HPGD 1342/4885TSHR 3599/4885MAPK1 2301/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.