Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776777 | 0.84 | METAP1 (0.49) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL23482061 | 0.82 | PLCG1 (0.52) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL30534254 | 0.82 | PLCG1 (0.52) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL2392457 | 0.78 | METAP1 (0.56) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL1479193 | 0.76 | METAP1 (0.47) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL15266282 | 0.76 | METAP1 (0.56) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL30668778 | 0.76 | METAP1 (0.56) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL6868944 | 0.76 | METAP1 (0.56) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL3243855 | 0.76 | METAP1 (0.56) | METAP1NAMPTPOLBLMNATDP2 | |
| SCHEMBL1699207 | 0.74 | ATR (0.56) | METAP1POLBLMNAATRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673088-A1 | 1,1,1- TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO¬2,3-C|PYRIDIN-2-YLMETHYL)PENTAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS GLUCOCORTICOID LIGANDS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND DIABETES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030213-A1 | 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-04-07 | — | — | WO | disclosed |