Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | TET3 | O43151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL5801291 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL465926 | 0.92 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL8799742 | 0.92 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL465928 | 0.92 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL17871053 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL17871055 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL646455 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL3061502 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL9719878 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL1533801 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006060445-A2 | METHODS FOR FORMULATING AND CUSTOMIZING A MICRONUTRIENT SUPPLEMENT | METAMETRIX, INC. (US) | 2006-06-08 | — | — | WO | disclosed |