Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202642 | 0.94 | CA14 (0.44) | CA14CA12CA1CA2CYP2D6 | |
| SCHEMBL2324579 | 0.82 | MEN1 (0.40) | CA14CA12CA1CA2CYP2D6 | |
| SCHEMBL3193199 | 0.82 | MEN1 (0.40) | CA14CA12CA1CA2CYP2D6 | |
| SCHEMBL3670762 | 0.78 | CYP2D6 (0.41) | CA14CA12CA1CA2CYP2D6 | |
| SCHEMBL7431200 | 0.77 | CA14 (0.46) | CA14CA12CA1CA2CYP2D6 | |
| SCHEMBL4095492 | 0.77 | CA14 (0.46) | CA14CA12CA1CA2CYP2D6 | |
| SCHEMBL29023037 | 0.74 | GAA (0.45) | CA14TSHR | |
| SCHEMBL5801336 | 0.74 | CA14 (0.46) | CA14CA12CA1CA2CA7 | |
| SCHEMBL13613755 | 0.74 | CA12 (0.44) | CA14CA12CA1CA2CA7 | |
| SCHEMBL14206399 | 0.73 | CA12 (0.50) | CA14CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636218-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005003128-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |