Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.56 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3690032 | 0.87 | MAP2K1 (0.62) | MAP2K1JAK3 | |
| SCHEMBL6054273 | 0.78 | MAP2K1 (0.61) | MAP2K1JAK1JAK3 | |
| SCHEMBL6054292 | 0.77 | MAP2K1 (0.61) | MAP2K1 | |
| SCHEMBL6054279 | 0.76 | MAP2K1 (0.59) | MAP2K1JAK1JAK3 | |
| SCHEMBL5137524 | 0.75 | MAP2K1 (0.55) | MAP2K1JAK1TYK2JAK2JAK3 | |
| SCHEMBL3698281 | 0.75 | MAP2K1 (0.83) | MAP2K1 | |
| SCHEMBL6054389 | 0.74 | MAP2K1 (0.64) | MAP2K1 | |
| SCHEMBL3687094 | 0.74 | MAP2K1 (0.76) | MAP2K1 | |
| SCHEMBL3690543 | 0.74 | MAP2K1 (0.80) | MAP2K1 | |
| SCHEMBL3692520 | 0.73 | MAP2K1 (0.77) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578351-A4 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BRISTOL MYERS SQUIBB CO (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1578351-A2 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Bristol-Myers Squibb Company (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2003082208-A2 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-09 | — | — | WO | disclosed |