Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | GFER | P55789 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 3/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10473262 | 0.98 | MAPT (0.66) | CYP1A2CYP3A4CYP2C19GFERMAPT | |
| SCHEMBL30577378 | 0.86 | HTR1D (0.60) | GAAALDH1A1DDB1CRBNHTR1A | |
| SCHEMBL4644779 | 0.85 | JAK2 (0.61) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1383637 | 0.85 | GAA (0.56) | CYP1A2CYP3A4CYP2C19MAPTGAA | |
| SCHEMBL30577363 | 0.85 | JAK2 (0.61) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL25319314 | 0.84 | MAPT (0.68) | CYP1A2CYP3A4CYP2C19MAPTGAA | |
| SCHEMBL6226704 | 0.84 | MAPT (0.67) | MAPTGAAALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3976781 | 0.84 | GAA (0.54) | CYP1A2CYP3A4CYP2C19MAPTGAA | |
| SCHEMBL4874352 | 0.83 | MAPT (0.62) | CYP1A2CYP3A4CYP2C19MAPTGAA | |
| SCHEMBL6689700 | 0.80 | GFER (1.00) | CYP1A2CYP3A4CYP2C19GFERMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641757-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004101522-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-11-25 | — | — | WO | disclosed |