SCHEMBL4874352

SCHEMBL4874352

NC(=O)Nc1cccc(N2CCCC2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.62
MEN1 O00255 5/20 0.62
KMT2A Q03164 5/20 0.62
USP2 O75604 3/20 0.62
KDM4E B2RXH2 3/20 0.62
ALDH1A1 P00352 3/20 0.62
POLB P06746 3/20 0.62
HPGD P15428 2/20 0.62
BLM P54132 1/20 0.62
GAA P10253 4/20 0.60
ALOX15 P16050 2/20 0.60
MAPK1 P28482 2/20 0.60
CNR1 P21554 4/20 0.59
TSHR P16473 1/20 0.58
KCNQ2 O43526 1/20 0.56
CNR2 P34972 1/20 0.54
HSD17B10 Q99714 1/20 0.53
HCRTR1 O43613 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3496105 0.86 KMO (0.56) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL22410915 0.86 HTR2A (0.59) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL25319314 0.85 MAPT (0.68) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL10473262 0.84 MAPT (0.66) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL5801780 0.83 CYP1A2 (0.67) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL1535782 0.80 NPC1 (0.69) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL23844235 0.80 MAPT (0.58) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL29950829 0.80 MAPT (0.73) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL4870289 0.80 ABL1 (0.45) MAPTMEN1KMT2AUSP2KDM4E
SCHEMBL5074701 0.80 MAPT (0.69) MAPTMEN1KMT2AUSP2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114502543-A Targeted protein compounds, pharmaceutical compositions and therapeutic applications thereof 拜欧斯瑞克斯公司 2022-05-13 CN disclosed
US-7455698-B2 Cationic dyes and dyestuff for keratin fibres containing said compounds WELLA AG (DE) 2008-11-25 US disclosed
US-20070258929-A1 Cationic Dyes and Dyestuff for Keratin Fibres Containing Said Compounds HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2007-11-08 US disclosed
CN-1968936-A Cationic dyes and dyeing agents for keratin fibres containing said compounds WELLA AG (DE) 2007-05-23 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070258929-A1 Cationic Dyes and Dyestuff for Keratin Fibres Containing Said Compounds KRT18, IK, S100A4 MAPT 317/4885MEN1 4349/4885KMT2A 619/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.