Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | ULK1 | O75385 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
| ▸ | CLK3 | P49761 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580721 | 0.91 | AURKA (0.59) | AURKAULK1RPS6KA5RPS6KA4PRKD3 | |
| SCHEMBL580530 | 0.85 | PDE10A (0.53) | AURKAAURKBPDE10A | |
| SCHEMBL581766 | 0.84 | AURKA (0.75) | AURKAULK1RPS6KA5RPS6KA4PRKD3 | |
| SCHEMBL580811 | 0.78 | AURKA (0.50) | AURKAULK1RPS6KA5RPS6KA4PRKD3 | |
| SCHEMBL581039 | 0.77 | AURKA (0.50) | AURKAULK1RPS6KA5RPS6KA4PRKD3 | |
| SCHEMBL580671 | 0.77 | AURKA (0.77) | AURKAULK1RPS6KA5RPS6KA4PRKD3 | |
| SCHEMBL580667 | 0.76 | AURKA (0.78) | AURKAULK1RPS6KA5RPS6KA4PRKD3 | |
| SCHEMBL581286 | 0.75 | AURKA (0.59) | AURKAULK1RPS6KA5RPS6KA4PRKD3 | |
| SCHEMBL581877 | 0.75 | PDE10A (0.50) | PDE10A | |
| SCHEMBL581376 | 0.74 | AURKA (0.71) | AURKAULK1RPS6KA5RPS6KA4PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |