Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.62 |
| ▸ | HTR2C | P28335 | 13/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.62 |
| ▸ | DRD2 | P14416 | 6/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802081 | 0.89 | HTR2A (0.63) | HTR2AHTR2CKCNH2DRD2MC4R | |
| SCHEMBL5737711 | 0.87 | HTR2A (0.56) | HTR2AHTR2CKCNH2DRD2MC4R | |
| SCHEMBL5213649 | 0.78 | HTR2A (0.64) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5210373 | 0.78 | HTR2A (0.63) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5213008 | 0.77 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL5210783 | 0.77 | HTR2A (0.62) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5210779 | 0.77 | HTR2A (0.62) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5209963 | 0.70 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL5210934 | 0.70 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL5820448 | 0.70 | HTR2A (0.43) | HTR2AHTR2CKCNH2DRD2MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641756-A1 | 4-ARYLSULPHONYLPIPERIDINE DERIVATIVES FOR ANTAGONISM OF THE 5-HT2A RECEPTOR | MERCK SHARP & DOHME LTD. (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004101518-A1 | 4-ARYLSULPHONYLPIPERIDINE DERIVATIVES FOR ANTAGONISM OF THE 5-HT2A RECEPTOR | MERCK SHARP & DOHME LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |