Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.62 |
| ▸ | HTR2C | P28335 | 9/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.62 |
| ▸ | DRD2 | P14416 | 6/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210783 | 1.00 | HTR2A (0.62) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5210373 | 0.88 | HTR2A (0.63) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5737711 | 0.80 | HTR2A (0.56) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5212366 | 0.78 | HTR2A (0.54) | HTR2AHTR2CKCNH2DRD2KDM4E | |
| SCHEMBL5802201 | 0.77 | HTR2A (0.62) | HTR2AHTR2CKCNH2DRD2PSEN1 | |
| SCHEMBL5245186 | 0.76 | HTR2A (0.51) | HTR2AHTR2CKCNH2DRD2OPRM1 | |
| SCHEMBL27646003 | 0.76 | HTR2A (0.53) | HTR2AHTR2CKCNH2DRD2OPRM1 | |
| SCHEMBL27646004 | 0.74 | HTR2A (0.54) | HTR2AHTR2CKCNH2DRD2KDM4E | |
| SCHEMBL5211501 | 0.72 | HTR2A (0.63) | HTR2AHTR2CKCNH2DRD2KDM4E | |
| SCHEMBL5213206 | 0.71 | HTR2A (0.71) | HTR2AHTR2CKCNH2DRD2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641756-B1 | 4-ARYLSULPHONYLPIPERIDINE DERIVATIVES FOR ANTAGONISM OF THE 5-HT2A RECEPTOR | MERCK SHARP & DOHME (GB) | 2007-04-11 | — | — | EP | disclosed |
| US-20060211735-A1 | 4-Arylsulphonylpiperidine derivatives for antagonism of the 5-ht2a receptor | MERCK SHARP & DOHME LTD. (GB) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211735-A1 | 4-Arylsulphonylpiperidine derivatives for antagonism of the 5-ht2a receptor | HTR2A, HTR2C, HTR5A | HTR2A 1/4885HTR2C 2/4885KCNH2 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.