Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372891 | 0.84 | CNR1 (0.39) | RXRARXRBRXRGMERTKPOLB | |
| SCHEMBL5377928 | 0.84 | RXRA (0.45) | RXRARXRBRXRGPOLBDRD4 | |
| SCHEMBL5374585 | 0.82 | RXRA (0.36) | RXRARXRBRXRGMERTKPOLB | |
| SCHEMBL5388444 | 0.82 | RXRA (0.36) | RXRARXRBRXRGMERTKPOLB | |
| SCHEMBL5374578 | 0.82 | RXRA (0.36) | RXRARXRBRXRGMERTKPOLB | |
| SCHEMBL5372228 | 0.81 | CYP4F2 (0.38) | RXRARXRBRXRGMERTKPOLB | |
| SCHEMBL6499080 | 0.81 | POLB (0.39) | RXRARXRBRXRGMERTKPOLB | |
| SCHEMBL5373390 | 0.79 | CSNK1A1 (0.38) | RXRARXRBRXRGGRIN2BCYP4F2 | |
| SCHEMBL7170915 | 0.78 | RXRA (0.40) | RXRARXRBRXRGPOLBGRIN2B | |
| SCHEMBL5375255 | 0.78 | KDM4E (0.42) | RXRARXRBRXRGMERTKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |
| WO-2002010137-A9 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARM INC (US) | 2003-02-06 | — | — | WO | disclosed |