Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 16/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | GLA | P06280 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.62 |
| ▸ | HBB | P68871 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | STAT6 | P42226 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803265 | 1.00 | TOP1 (0.62) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL15149692 | 0.92 | TOP1 (0.58) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL25932514 | 0.90 | TOP1 (0.58) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL15080455 | 0.90 | TOP1 (0.55) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL23864716 | 0.88 | TOP1 (0.65) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8992627 | 0.88 | TOP1 (0.65) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL16003109 | 0.87 | TOP1 (0.61) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL15080454 | 0.87 | TOP1 (0.61) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL15184632 | 0.87 | TOP1 (0.61) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL9389976 | 0.87 | TOP1 (0.53) | TOP1ALDH1A1SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230241241-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-08-03 | — | — | US | disclosed |
| EP-4196166-A2 | PEPTIDES AND FORMULATIONS FOR CANCER TREATMENT | Peptinovo Biopharma Inc. (US) | 2023-06-21 | — | — | EP | disclosed |
| EP-4168009-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | Hangzhou DAC Biotech Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| CN-115505472-A | Brewing process of health wine containing camptotheca acuminate and ginseng | 上海正数新能源科技有限公司 | 2022-12-23 | — | — | CN | disclosed |
| WO-2021212638-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2021-10-28 | — | — | WO | disclosed |
| WO-2021212638-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2021-10-28 | — | — | WO | disclosed |
| EP-3332811-A1 | CYCLODEXTRIN-BASED POLYMERS FOR DELIVERING COVALENTLY ATTACHED CAMPTOTHECIN | Cerulean Pharma Inc. (US) | 2018-06-13 | — | — | EP | disclosed |
| US-9550860-B2 | Cyclodextrin-based polymers for therapeutics delivery | CERULEAN PHARMA INC. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20140288023-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY | CERULEAN PHARMA INC. (US) | 2014-09-25 | — | — | US | disclosed |
| WO-2014085575-A1 | METHODS FOR TREATING CANCER USING COMBINATION THERAPIES | ENDOCYTE, INC. (US) | 2014-06-05 | — | — | WO | disclosed |
| US-5910491-A | Highly lipophilic camptothecin derivatives | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1999-06-08 | — | — | US | disclosed |
| WO-1998007727-A1 | HIGHLY LIPOPHILIC CAMPTOTHECIN DERIVATIVES | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1998-02-26 | — | — | WO | disclosed |
| EP-0686158-B1 | METHODS FOR PURIFYING 20(S)-CAMPTOTHECIN | STEHLIN FOUNDATION FOR CANCER (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5608066-A | Methods for purifying camptothecin compounds | THE STEHLIN FOUNDATION FOR CANCER RESEARCH (US) | 1997-03-04 | — | — | US | disclosed |
| US-5527913-A | Methods for purifying camptothecin compounds | THE STEHLIN FOUNDATION FOR CANCER RESEARCH (US) | 1996-06-18 | — | — | US | disclosed |
| EP-0686158-A1 | METHODS FOR PURIFYING 20(S)-CAMPTOTHECIN | THE STEHLIN FOUNDATION FOR CANCER RESEARCH (US) | 1995-12-13 | — | — | EP | disclosed |
| US-5352789-A | Methods for purifying camptothecin compounds | THE STEHLIN FOUNDATION FOR CANCER RESEARCH (US) | 1994-10-04 | — | — | US | disclosed |
| WO-1994019353-A1 | METHODS FOR PURIFYING 20(S)-CAMPTOTHECIN | THE STEHLIN FOUNDATION FOR CANCER RESEARCH (US) | 1994-09-01 | — | — | WO | disclosed |
| WO-1994005672-A1 | PROCESS FOR PREPARING CERTAIN PYRROLO[3,4- b]QUINOLINES, CERTAIN 1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO[1,2-b]QUINOLIN-9(11H)-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5061800-A | ANTITUMOR AGENTS | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1991-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288023-A1 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY | DDOST, DSC1, SI | TOP1 922/4885ALDH1A1 3595/4885SMN1; SMN2 1514/4885 |
| US-20230241241-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | CD4, DCLRE1A, TOP1 | TOP1 3/4885ALDH1A1 3405/4885SMN1; SMN2 4335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.