Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 9/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.54 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580111 | 1.00 | TEK (0.56) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580723 | 0.81 | AURKB (0.71) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581575 | 0.81 | AURKB (0.71) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581083 | 0.81 | AURKB (0.68) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581161 | 0.80 | TEK (0.60) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580629 | 0.80 | AURKB (0.72) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580561 | 0.80 | AURKB (0.57) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580237 | 0.80 | AURKB (0.57) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581474 | 0.79 | TEK (0.68) | TEKAURKBAURKATPX2 | |
| SCHEMBL581801 | 0.75 | AURKB (0.71) | TEKAURKBAURKATPX2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2418209-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2418209-A1 | Aurora kinase modulators and method of use | Amgen Inc. (US) | 2012-02-15 | — | — | EP | disclosed |