Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 20/20 | 0.77 |
| ▸ | MMP13 | P45452 | 20/20 | 0.77 |
| ▸ | MMP14 | P50281 | 3/20 | 0.71 |
| ▸ | MMP9 | P14780 | 2/20 | 0.71 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.71 |
| ▸ | MMP1 | P03956 | 1/20 | 0.68 |
| ▸ | MMP3 | P08254 | 1/20 | 0.68 |
| ▸ | MMP7 | P09237 | 1/20 | 0.68 |
| ▸ | MMP8 | P22894 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3615957 | 1.00 | MMP2 (0.77) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3616150 | 0.92 | MMP2 (0.65) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3618262 | 0.91 | MMP2 (0.82) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL5802508 | 0.87 | MMP2 (0.79) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3606959 | 0.87 | MMP2 (0.79) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3609251 | 0.87 | MMP2 (0.88) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3611937 | 0.87 | MMP2 (1.00) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3619088 | 0.86 | MMP2 (1.00) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3619093 | 0.86 | MMP2 (1.00) | MMP2MMP13MMP14MMP9ADAMTS4 | |
| SCHEMBL3616918 | 0.86 | MMP2 (1.00) | MMP2MMP13MMP14MMP9ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692124-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | claimed |