Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.67 |
| ▸ | FBP1 | P09467 | 2/20 | 0.65 |
| ▸ | VCP | P55072 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819754 | 1.00 | NFE2L2 (0.67) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL15498134 | 0.85 | NFE2L2 (0.89) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL29453878 | 0.85 | NFE2L2 (0.65) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL100242 | 0.85 | NFE2L2 (0.65) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL100241 | 0.85 | NFE2L2 (0.65) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL2062219 | 0.85 | NFE2L2 (0.65) | NFE2L2FBP1VCPCYP19A1MAPT | |
| Benzene SCHEMBL28683414 | 0.83 | NFE2L2 (0.68) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL11301074 | 0.82 | CYP19A1 (0.93) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL11301072 | 0.82 | CYP19A1 (0.93) | NFE2L2FBP1VCPCYP19A1MAPT | |
| SCHEMBL1405314 | 0.80 | NFE2L2 (1.00) | NFE2L2FBP1VCPCYP19A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410696-A | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-10-18 | — | — | US | claimed |
| EP-0075629-A1 | Imidazole derivatives, their preparation, and their pharmaceutical compositions | Sumitomo Chemical Industries Ltd. (JP) | 1983-04-06 | — | — | EP | claimed |
| CN-109761941-A | 2- (benzofuran -7- oxygroup)-N '-substituted aryl/alkyl acetoacetates hydazone derivative and the preparation method and application thereof | 河北大学 | 2019-05-17 | — | — | CN | disclosed |
| CN-106380442-A | Preparation method of calcium ion channel antagonist manidipine | 张家港威胜生物医药有限公司 | 2017-02-08 | — | — | CN | disclosed |
| WO-2005089515-A9 | METHODS FOR THE TREATMENT OF SYNUCLEINOPATHIES | BRIGHAM & WOMENS HOSPITAL (US) | 2006-01-26 | — | — | WO | disclosed |
| US-6528655-B1 | Hydroxyphenyl diamido derivatives | PHARMACOR, INC. (CA) | 2003-03-04 | — | — | US | disclosed |
| US-4495192-A | HYPOTENSIVE AGENTS; VASODILATORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-22 | — | — | US | disclosed |
| US-4410696-A | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4352928-A | ANTIINFLAMMATORY, HYPOGLYCEMIC, ANTICOAGULANT, ANOREXIGENIC, SEROTONIN EFFEC | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |
| EP-0022481-A1 | 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions | Mitsubishi Yuka Pharmaceutical Co., Ltd. (JP) | 1981-01-21 | — | — | EP | disclosed |