Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455617 | 0.81 | TSHR (0.58) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL1708997 | 0.80 | TSHR (0.60) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL14627980 | 0.79 | TSHR (0.71) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL16002861 | 0.78 | TSHR (0.59) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL28088879 | 0.78 | TSHR (0.52) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL4079342 | 0.78 | TSHR (0.69) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL3790371 | 0.77 | GRIN2B (0.53) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL13059812 | 0.77 | GRIN2B (0.53) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL5475839 | 0.77 | HSD11B1 (0.55) | TSHRGAAMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL5475835 | 0.77 | HSD11B1 (0.55) | TSHRGAAMAPK1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071958-A1 | COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-07-06 | — | — | WO | disclosed |