Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | STAT6 | P42226 | 7/20 | 0.46 |
| ▸ | ESR1 | P03372 | 7/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203451 | 0.73 | GSK3B (0.67) | GSK3AGSK3BRPS6KA3 | |
| SCHEMBL2812923 | 0.69 | ESR2 (0.47) | ESR1ESR2ADORA3ADORA2AADORA2B | |
| SCHEMBL5805926 | 0.68 | RPS6KA3 (0.50) | STAT6ESR1ESR2ULK1RPS6KA3 | |
| SCHEMBL5816142 | 0.68 | GSK3A (0.60) | GSK3AGSK3BSTAT6ESR1ESR2 | |
| SCHEMBL1183990 | 0.65 | KDR (0.67) | — | |
| SCHEMBL1184353 | 0.64 | KDR (0.60) | — | |
| SCHEMBL10999332 | 0.63 | HDAC3 (0.51) | STAT6ADORA3ADORA2AADORA2BADORA1 | |
| Phenol SCHEMBL28213597 | 0.63 | KDM4E (0.50) | GSK3AGSK3BESR1ESR2NPC1 | |
| SCHEMBL7090103 | 0.62 | STAT6 (0.48) | GSK3AGSK3BSTAT6ESR1ESR2 | |
| SCHEMBL21502557 | 0.62 | SCN9A (0.42) | GSK3AGSK3BNPC1RAB9ARPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |