Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435666 | 0.74 | EGFR (0.79) | EGFRCSF1RHDAC3HDAC1HDAC2 | |
| SCHEMBL15336038 | 0.70 | CCNB2 (0.49) | RIPK1ADORA2AADORA1CCNB2CDK1 | |
| SCHEMBL27857052 | 0.69 | APP (0.57) | EGFRHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL10999332 | 0.68 | HDAC3 (0.51) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22191357 | 0.68 | HDAC3 (0.60) | EGFRHDAC3HDAC1HDAC2HDAC6 | |
| Hydrochloric Acid SCHEMBL10585056 | 0.67 | APP (0.56) | EGFRHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL11084759 | 0.66 | STAT6 (0.58) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL17186572 | 0.66 | APP (0.54) | EGFRHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL6257376 | 0.65 | EGFR (0.61) | EGFRCSF1RHDAC3HDAC1HDAC2 | |
| SCHEMBL22151175 | 0.65 | APP (0.64) | ESR1ESR2ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332368-A2 | METHODS FOR DETECTING THE EFFICACY OF ANTICANCER TREATMENTS | Board of Regents, The University of Texas System (US) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002039121-A2 | METHODS FOR DETECTING THE EFFICACY OF ANTICANCER TREATMENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-05-16 | — | — | WO | disclosed |