Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.86 |
| ▸ | MAPT | P10636 | 1/20 | 0.86 |
| ▸ | PDE4A | P27815 | 1/20 | 0.86 |
| ▸ | KDR | P35968 | 1/20 | 0.86 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28282689 | 1.00 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL8750161 | 1.00 | — | — | |
| Piperazine SCHEMBL28418809 | 1.00 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28015401 | 1.00 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL379769 | 1.00 | — | — | |
| Water SCHEMBL28941037 | 1.00 | HIF1A (0.86) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Hydrochloric Acid SCHEMBL28472109 | 0.94 | HIF1A (0.75) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Hydrochloric Acid SCHEMBL28465717 | 0.94 | HIF1A (0.75) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28525307 | 0.94 | HIF1A (0.75) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL10439207 | 0.94 | HIF1A (0.75) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1277 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503403-B2 | Method of producing aluminum hydroxide-coated SiC particles, dispersion solution and molded body containing same, and sintered body formed using same | FUJIMI INCORPORATED (JP) | 2025-12-23 | — | — | US | claimed |
| EP-3919462-B1 | METHOD FOR OBTAINING A SIC COATED PARTICLE, A DISPERSION SOLUTION AND A MOLDED BODY CONTAINING SAME, AND A SINTERED BODY FORMED USING SAME | FUJIMI INC (JP) | 2025-03-12 | — | — | EP | claimed |
| CN-116178114-B | Method for separating cresol isomers by complexation extraction method | 中触媒新材料股份有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-117820002-B | Method for preparing high-frequency high-permeability manganese zinc ferrite | 深圳信义磁性材料有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-118126029-A | Preparation method of piribedil | 南昌大学抚州医学院 | 2024-06-04 | — | — | CN | claimed |
| CN-117820002-A | Method for preparing high-frequency high-permeability manganese zinc ferrite | 深圳信义磁性材料有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-117511412-A | Chemical mechanical polishing solution and polishing method thereof | 深圳清华大学研究院 | 2024-02-06 | — | — | CN | claimed |
| CN-114405292-B | Composite nanofiltration membrane modified by ionic liquid and preparation method and application thereof | 苏州仕净科技股份有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-116651220-A | Preparation method of interfacial polymerization positively charged hybrid composite nanofiltration membrane | 浙江工业大学 | 2023-08-29 | — | — | CN | claimed |
| CN-113365964-B | Coated particles, dispersion and molded body containing same, and sintered body formed using same | 福吉米株式会社 | 2023-07-21 | — | — | CN | claimed |
| US-6280652-B1 | POLISHING EDGE SURFACE OF SILICON WAFERS OR OXIDE FILM-COATED SEMICONDUCTOR WAFERS WITH FORMULATION COMPRISING WATER, SILICON DIOXIDE SELECTED FORM COLLOIDAL SILICA, FUMED SILICA, AND PRECIPITATED SILICA | FUJIMI INCORPORATED (JP) | 2001-08-28 | — | — | US | claimed |
| EP-0994137-A2 | Polyurethane hybrid dispersions and coatings having increased wet adhesion and solvent resistance | National Starch and Chemical Investment Holding Corporation (US) | 2000-04-19 | — | — | EP | claimed |
| US-6031041-A | A CURABLE BLENDS COMPRISING A CARBOXYLATED POLYURETHANE DISPERSION AND A FUNCTIONALIZED POLYMER WHICH IS PREPARED IN THE PRESENCE OF THE CARBOXYLATED POLYURETHANE DISPERSION; EXHIBIT IMPROVED WET ADHESION TO ALKYD SUBSTRATES | NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) | 2000-02-29 | — | — | US | claimed |
| CN-1238365-A | Edge polishing composition | FUJIMI INC (JP) | 1999-12-15 | — | — | CN | claimed |
| EP-0962508-A1 | Wafer edge polishing composition | FUJIMI INCORPORATED (JP) | 1999-12-08 | — | — | EP | claimed |
| EP-0044916-B1 | PROCESS AND APPARATUS FOR THE SEPARATION OF SULFUR DIOXIDE AND OTHER POLLUTANTS FROM FLUE GAS | Hölter, Heinz, Dipl.-Ing. (DE) | 1987-01-21 | — | — | EP | claimed |
| US-4399240-A | Removal of acrylonitrile from latex with saturated heterocyclic amines | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1983-08-16 | — | — | US | claimed |
| US-4388281-A | Noxious-component removal from flue gas and compositions useful therefor | HOELTER HEINZ (DE) | 1983-06-14 | — | — | US | claimed |
| EP-0044916-A2 | Process and apparatus for the separation of sulfur dioxide and other pollutants from flue gas | Hölter, Heinz, Dipl.-Ing. (DE) | 1982-02-03 | — | — | EP | claimed |
| US-4264770-A | Process for preparing 1,4-bis-piperonylpiperazine and similar compounds | FARMACEUTICI GEYMONAT SUD S.P.A. (IT) | 1981-04-28 | — | — | US | claimed |