Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.74 |
| ▸ | GSK3A | P49840 | 3/20 | 0.74 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.47 |
| ▸ | MERTK | Q12866 | 5/20 | 0.47 |
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL385263 | 0.96 | GSK3A (0.70) | GSK3BGSK3AMAPK8MAPK9TYRO3 | |
| SCHEMBL385264 | 0.96 | GSK3A (0.70) | GSK3BGSK3AMAPK8MAPK9TYRO3 | |
| SCHEMBL17544767 | 0.93 | GSK3B (0.64) | GSK3BGSK3AMAPK8PRKCQCDK2 | |
| SCHEMBL6890352 | 0.91 | GSK3A (0.64) | GSK3BGSK3AMAPK8MAPK9TYRO3 | |
| SCHEMBL14685715 | 0.91 | GSK3A (0.64) | GSK3BGSK3AMAPK8MAPK9TYRO3 | |
| SCHEMBL1961567 | 0.91 | GSK3A (0.64) | GSK3BGSK3AMAPK8MAPK9TYRO3 | |
| SCHEMBL14589028 | 0.85 | GSK3A (0.57) | GSK3BGSK3AMAPK8MAPK9AXL | |
| SCHEMBL1265078 | 0.85 | GSK3A (0.57) | GSK3BGSK3AMAPK8MAPK9AXL | |
| SCHEMBL1265079 | 0.85 | GSK3A (0.57) | GSK3BGSK3AMAPK8MAPK9AXL | |
| SCHEMBL5806770 | 0.84 | GSK3A (0.82) | GSK3BGSK3AMAPK8MAPK9TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | claimed |
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |