Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.47 |
| ▸ | MERTK | Q12866 | 5/20 | 0.47 |
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
| ▸ | MYLK | Q15746 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14685715 | 1.00 | GSK3A (0.64) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL6890352 | 1.00 | GSK3A (0.64) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL5806595 | 0.91 | GSK3B (0.74) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL385264 | 0.87 | GSK3A (0.70) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL385263 | 0.87 | GSK3A (0.70) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL14674436 | 0.87 | GSK3B (0.48) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL17544767 | 0.84 | GSK3B (0.64) | GSK3AGSK3BMAPK8PRKCQ | |
| SCHEMBL20837953 | 0.82 | GSK3B (0.55) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL17649879 | 0.82 | GSK3B (0.55) | GSK3AGSK3BTYRO3MERTKAXL | |
| SCHEMBL17649882 | 0.82 | GSK3B (0.55) | GSK3AGSK3BTYRO3MERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130034495-A1 | ISOTOPOLOGUES OF 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2,4,6-TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-YLAMINO]-CYCLOHEXAN-1-OL | SIGNAL PHARMACEUTICALS, LLC | 2013-02-07 | — | — | US | disclosed |
| WO-2011071491-A1 | ISOTOPOLOGUES OF 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2, 4, 6- TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-YLAMINO]-CYCLOHEXAN-1-OL | SIGNAL PHARMACEUTICALS, LLC (US) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130034495-A1 | ISOTOPOLOGUES OF 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2,4,6-TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-YLAMINO]-CYCLOHEXAN-1-OL | DHPS, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CPT1A | GSK3A 3614/4885GSK3B 3811/4885TYRO3 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.