Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 5/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246294 | 0.90 | MAPK11 (0.55) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL5812295 | 0.88 | MAPK13 (0.53) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL5811657 | 0.88 | MAPK11 (0.54) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL5808499 | 0.84 | MAPK13 (0.48) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL4243633 | 0.83 | MAPK13 (0.49) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL4245986 | 0.83 | MAPK13 (0.53) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL5812461 | 0.83 | MAPK11 (0.51) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL4245202 | 0.82 | MAPK13 (0.53) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL4760876 | 0.82 | MAPK13 (0.51) | MAPK13MAPK11CYP2C9MAPK14MAPK12 | |
| SCHEMBL4246031 | 0.81 | MAPK13 (0.49) | MAPK13MAPK11CYP2C9MAPK14MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |