SCHEMBL5806986

SCHEMBL5806986

COc1cccc(Cn2c(C)c(C)c3ccnc(OCC4CCCO4)c32)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.53
GRIN1 Q05586 1/20 0.41
GRIN2B Q13224 1/20 0.41
POLB P06746 2/20 0.39
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
GPR84 Q9NQS5 2/20 0.39
PDE1A P54750 1/20 0.39
PDE1B Q01064 1/20 0.39
PDE1C Q14123 1/20 0.39
FABP4 P15090 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
ROCK2 O75116 2/20 0.38
ROCK1 Q13464 1/20 0.38
HPGD P15428 2/20 0.38
IRAK4 Q9NWZ3 1/20 0.38
DRD4 P21917 1/20 0.38
LMNA P02545 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5808660 0.99 ALDH1A1 (0.53) ALDH1A1GRIN1GRIN2BPOLBGAA
Hydrochloric Acid SCHEMBL5811801 0.89 POLB (0.42) ALDH1A1POLBNPSR1GPR84SMN1; SMN2
SCHEMBL5811355 0.89 DRD4 (0.43) ALDH1A1POLBNPSR1GPR84SMN1; SMN2
Hydrochloric Acid SCHEMBL5810337 0.88 DRD4 (0.42) ALDH1A1POLBNPSR1GPR84SMN1; SMN2
Hydrochloric Acid SCHEMBL5811020 0.88 ATM (0.41) ALDH1A1POLBNPSR1PDE1APDE1B
Hydrochloric Acid SCHEMBL5808939 0.87 POLB (0.45) ALDH1A1POLBNPSR1FABP4SMN1; SMN2
Hydrochloric Acid SCHEMBL5806587 0.84 EPHA2 (0.41) ALDH1A1POLBGAANPSR1SMN1; SMN2
Hydrochloric Acid SCHEMBL5810257 0.82 DRD4 (0.45) POLBNPSR1IRAK4DRD4NPC1
Hydrochloric Acid SCHEMBL5807172 0.81 DRD4 (0.39) POLBNPSR1GPR84IRAK4DRD4
Hydrochloric Acid SCHEMBL5808922 0.80 PPARG (0.44) POLBNPSR1IRAK4DRD4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006025717-A1 PYRROLO[2,3-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO disclosed