Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2697697 | 0.69 | HTT (0.48) | LMNAHTTNPC1RAB9AMAPT | |
| SCHEMBL4445956 | 0.68 | JAK3 (0.39) | LMNARAB9AMAPTMEN1KMT2A | |
| SCHEMBL27947892 | 0.65 | CDK2 (0.44) | CDK2HTTNPC1RAB9AMAPT | |
| SCHEMBL16740681 | 0.65 | CDK2 (0.41) | CDK2MAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL20089106 | 0.64 | ALDH1A1 (0.48) | LMNAHTTMAPTALDH1A1CYP1A2 | |
| SCHEMBL4343312 | 0.64 | JAK3 (0.37) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31570637 | 0.61 | MAPT (0.40) | RAB9AMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL15147678 | 0.61 | KDR (0.35) | CDK2LMNANPC1RAB9AMAPT | |
| SCHEMBL939117 | 0.61 | ALDH1A1 (0.54) | HTTMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL30574858 | 0.61 | ALDH1A1 (0.54) | HTTMAPTALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |