SCHEMBL5807650

SCHEMBL5807650

CN(C)CC(=Cc1ccc(C(=O)NO)cc1)CCOc1cccc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 2/20 0.48
HTR1B P28222 5/20 0.44
ALDH1A1 P00352 3/20 0.43
GAA P10253 2/20 0.43
MAPT P10636 1/20 0.43
HPGD P15428 3/20 0.43
KDM4E B2RXH2 2/20 0.43
HDAC6 Q9UBN7 4/20 0.41
HDAC8 Q9BY41 3/20 0.41
HDAC1 Q13547 3/20 0.41
HDAC3 O15379 2/20 0.41
HDAC4 P56524 2/20 0.41
HDAC7 Q8WUI4 2/20 0.41
HDAC2 Q92769 2/20 0.41
HDAC10 Q969S8 2/20 0.41
HDAC11 Q96DB2 2/20 0.41
HDAC9 Q9UKV0 2/20 0.41
HDAC5 Q9UQL6 2/20 0.41
TSHR P16473 1/20 0.41
HTR1D P28221 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5807646 1.00 P2RX3 (0.48) P2RX3HTR1BALDH1A1GAAMAPT
SCHEMBL5796949 0.89 HTR1B (0.45) HTR1BALDH1A1GAAMAPTHPGD
SCHEMBL5796948 0.89 HTR1B (0.45) HTR1BALDH1A1GAAMAPTHPGD
SCHEMBL5795610 0.85 P2RX3 (0.51) P2RX3ALDH1A1GAAMAPTHPGD
SCHEMBL5795607 0.85 P2RX3 (0.51) P2RX3ALDH1A1GAAMAPTHPGD
SCHEMBL5810052 0.83 P2RX3 (0.49) P2RX3ALDH1A1GAAMAPTHPGD
SCHEMBL5810050 0.83 P2RX3 (0.49) P2RX3ALDH1A1GAAMAPTHPGD
SCHEMBL5797861 0.82 P2RX3 (0.46) P2RX3ALDH1A1GAAMAPTHDAC6
SCHEMBL5797858 0.82 P2RX3 (0.46) P2RX3ALDH1A1GAAMAPTHDAC6
SCHEMBL5807110 0.82 P2RX3 (0.49) P2RX3ALDH1A1GAAMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006025683-A1 ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2006-03-09 WO disclosed